Enhanced Tau Aggregation in the Presence of Amyloid β
نویسندگان
چکیده
منابع مشابه
Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau.
OBJECTIVE To elucidate the relationship between the 2 hallmark proteins of Alzheimer disease (AD), amyloid-(Aβ) and tau, and clinical decline over time among cognitively normal older individuals. DESIGN A longitudinal cohort of clinically and cognitively normal older individuals assessed with baseline lumbar puncture and longitudinal clinical assessments. SETTING Research centers across the...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2017
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2017.03.011